Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hormones and Bone Tissue01:17

Hormones and Bone Tissue

4.3K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
4.3K
The Functions of the Skeletal System01:22

The Functions of the Skeletal System

7.8K
The most apparent functions of the skeletal system are support, protection, and movement. However, bone tissue also performs several other critical metabolic functions. For one, the bone matrix acts as a reservoir for a number of minerals important to the functioning of the body, especially calcium and phosphorus. These minerals, present in the bone tissue, can be released back into the bloodstream when required. Calcium ions, for example, are essential for muscle contractions and controlling...
7.8K
The Bone Matrix01:18

The Bone Matrix

10.2K
Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in...
10.2K
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

6.1K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
6.1K
Bone Disorders01:29

Bone Disorders

8.8K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
8.8K
Bone Remodeling01:40

Bone Remodeling

41.3K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
41.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Roles of Del-1 in effects of hyponatremia on muscle and bone in mice.

Bone·2026
Same author

Systemic administration of osteoblast-derived collagenase released extracellular vesicles restores trabecular bone loss in ovariectomized mice.

Bone·2026
Same author

Tmem119 is involved in the bone repair enhanced by parathyroid hormone in female mice.

The Journal of endocrinology·2026
Same author

The role of Tmem119 in the estrogen action on bone in mice.

Journal of bone and mineral metabolism·2025
Same author

Roles of plasminogen activator inhibitor-1 in aging-related muscle and bone loss in mice.

Aging·2025
Same author

Bone-muscle interactions.

Osteoporosis and sarcopenia·2025

Related Experiment Video

Updated: Apr 19, 2026

Using Real-Time Cell Metabolic Flux Analyzer to Monitor Osteoblast Bioenergetics
09:43

Using Real-Time Cell Metabolic Flux Analyzer to Monitor Osteoblast Bioenergetics

Published on: March 1, 2022

3.9K

Interactions between muscle tissues and bone metabolism.

Naoyuki Kawao1, Hiroshi Kaji

  • 1Department of Physiology and Regenerative Medicine, Kinki University Faculty of Medicine, Osakasayama, Japan.

Journal of Cellular Biochemistry
|December 19, 2014
PubMed
Summary

Sarcopenia and osteoporosis are linked to locomotive syndrome in aging populations. Muscle and bone health are interconnected, with factors like Tmem119 and osteoglycin potentially mediating their relationship.

Keywords:
BONEMUSCLEOSTEOPOROSISSARCOPENIA

More Related Videos

Subject-specific Musculoskeletal Model for Studying Bone Strain During Dynamic Motion
09:32

Subject-specific Musculoskeletal Model for Studying Bone Strain During Dynamic Motion

Published on: April 11, 2018

10.5K
Assessing Energy Substrate Oxidation In Vitro with 14CO2 Trapping
09:20

Assessing Energy Substrate Oxidation In Vitro with 14CO2 Trapping

Published on: March 23, 2022

2.7K

Related Experiment Videos

Last Updated: Apr 19, 2026

Using Real-Time Cell Metabolic Flux Analyzer to Monitor Osteoblast Bioenergetics
09:43

Using Real-Time Cell Metabolic Flux Analyzer to Monitor Osteoblast Bioenergetics

Published on: March 1, 2022

3.9K
Subject-specific Musculoskeletal Model for Studying Bone Strain During Dynamic Motion
09:32

Subject-specific Musculoskeletal Model for Studying Bone Strain During Dynamic Motion

Published on: April 11, 2018

10.5K
Assessing Energy Substrate Oxidation In Vitro with 14CO2 Trapping
09:20

Assessing Energy Substrate Oxidation In Vitro with 14CO2 Trapping

Published on: March 23, 2022

2.7K

Area of Science:

  • Biogerontology
  • Musculoskeletal Biology
  • Cell Biology

Background:

  • Sarcopenia (decreased muscle mass/function) and osteoporosis (reduced bone mass) are increasingly prevalent in older adults, impacting mobility.
  • Clinical data suggest a positive correlation between muscle mass, bone mass, and fracture risk.
  • Interactions between muscle and bone are influenced by genetic, endocrine, mechanical, inflammatory, and nutritional factors.

Purpose of the Study:

  • To explore the intricate physiological and pathological mechanisms underlying the interaction between skeletal muscle and bone metabolism.
  • To identify key molecular factors involved in muscle-bone crosstalk.

Main Methods:

  • Review of existing clinical and basic research data on sarcopenia, osteoporosis, and locomotive syndrome.
  • Analysis of genetic associations (e.g., myostatin, α-actinin 3) and molecular signaling pathways.
  • Investigation of specific cellular and humoral factors involved in muscle-bone interactions.

Main Results:

  • Tmem119 identified as a potential key factor in myoprogenitor cell differentiation into osteoblasts.
  • Osteoglycin and FAM5C proposed as muscle-derived humoral osteogenic factors.
  • Several other factors (myostatin, osteonectin, IGF-I, irisin, osteocalcin) implicated in muscle-bone crosstalk.

Conclusions:

  • The relationship between sarcopenia and osteoporosis is complex, involving shared genetic and molecular pathways.
  • Specific molecules like Tmem119, osteoglycin, and FAM5C are crucial in mediating the communication between muscle and bone.
  • Further research is needed to fully elucidate the mechanisms of muscle-bone interaction for therapeutic development.