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A common site for immortalizing proviral integrations in Friend erythroleukemia: molecular cloning and
R Paul1, S Schuetze, S L Kozak
1Department of Biochemistry, School of Medicine, Oregon Health Sciences University, Portland 97201-3098.
Journal of Virology
|November 1, 1989
Abstract:
By using a tagged derivative of Friend spleen focus-forming virus, we previously obtained evidence that proviral integration(s) in the host genome can cause erythroblast immortality by abrogating the commitment of the cell to differentiate (C. Spiro, B. Gliniak, and D. Kabat, J. Virol. 62:4129-4135, 1988). Exploiting the fact that each leukemia was a single clone that contained one tagged provirus, we have now molecularly cloned and characterized one common genomic site for immortalizing proviral integrations.