Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

5.6K
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
5.6K
Urologic Endoscopic Procedure: Cystoscopic Examination01:28

Urologic Endoscopic Procedure: Cystoscopic Examination

6.2K
Meaning of Cystoscopic Examination:Cystoscopy is an essential diagnostic tool in urology that is used to assess the structure and function of the genitourinary system. It provides a direct view of the urethra, bladder, and, in some cases, the ureteral openings. This procedure helps detect structural abnormalities, infections, cancers, and blockages in the urinary tract. There are two types of cystoscopy:Flexible cystoscopy is commonly performed in outpatient settings due to its less invasive...
6.2K
Imaging Studies IV: Magnetic Resonance Imaging01:27

Imaging Studies IV: Magnetic Resonance Imaging

398
Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...
398
Urinary Tract Calculi VI: Surgical Management01:25

Urinary Tract Calculi VI: Surgical Management

945
Procedures for Kidney StonesMedical intervention is necessary when kidney stones or renal calculi are too large to pass spontaneously (typically greater than 5 millimeters) when stones are accompanied by symptomatic infection (such as fever or pyelonephritis), when they impair kidney function, or when they cause persistent symptoms like severe pain, nausea, or urinary retention. Additionally, patients with only one kidney or those who cannot be treated with medical management also require...
945

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

First Report of Laparoscopic Radical Nephroureterectomy Following Extraperitoneal Tubeless Umbilical Cutaneous Ureterostomy.

IJU case reports·2026
Same author

Baseline analysis of patient reported outcomes in the progressive familial intrahepatic cholestasis patient registry.

Journal of pediatric gastroenterology and nutrition·2026
Same author

Pharmacokinetic Monitoring of JAK Inhibitor and Tacrolimus for Safe and Effective Management of Graft-Versus-Host Disease After Pediatric Liver Transplantation.

Pediatric transplantation·2025
Same author

Deriving Human Intestinal Organoids with Functional Tissue-Resident Macrophages All From Pluripotent Stem Cells.

Cellular and molecular gastroenterology and hepatology·2024
Same author

Portal vein hypoplasia is present in patients with biliary atresia at the time of diagnosis.

Journal of pediatric gastroenterology and nutrition·2024
Same author

Induced pluripotent stem cell (iPSC) modeling validates reduced GBE1 enzyme activity due to a novel variant, p.Ile694Asn, found in a patient with suspected glycogen storage disease IV.

Molecular genetics and metabolism reports·2024

Related Experiment Video

Updated: Apr 19, 2026

Patient-derived Orthotopic Xenograft Models for Human Urothelial Cell Carcinoma and Colorectal Cancer Tumor Growth and Spontaneous Metastasis
09:28

Patient-derived Orthotopic Xenograft Models for Human Urothelial Cell Carcinoma and Colorectal Cancer Tumor Growth and Spontaneous Metastasis

Published on: May 12, 2019

11.0K

Met in urological cancers.

Yasuyoshi Miyata1, Akihiro Asai2, Kensuke Mitsunari3

  • 1Department of Urology, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan. int.doc.miya@m3.dion.ne.jp.

Cancers
|December 19, 2014
PubMed
Summary

The Met receptor tyrosine kinase signaling pathway is crucial in urological cancers like prostate and kidney cancer. Targeting Met offers a promising therapeutic strategy for these malignancies.

More Related Videos

Technical Modification of the Terminal Ureter During Total Transperitoneal Laparoscopic Nephroureterectomy for Upper Urinary Tract Urothelial Carcinoma
06:39

Technical Modification of the Terminal Ureter During Total Transperitoneal Laparoscopic Nephroureterectomy for Upper Urinary Tract Urothelial Carcinoma

Published on: November 22, 2019

8.4K
A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

14.1K

Related Experiment Videos

Last Updated: Apr 19, 2026

Patient-derived Orthotopic Xenograft Models for Human Urothelial Cell Carcinoma and Colorectal Cancer Tumor Growth and Spontaneous Metastasis
09:28

Patient-derived Orthotopic Xenograft Models for Human Urothelial Cell Carcinoma and Colorectal Cancer Tumor Growth and Spontaneous Metastasis

Published on: May 12, 2019

11.0K
Technical Modification of the Terminal Ureter During Total Transperitoneal Laparoscopic Nephroureterectomy for Upper Urinary Tract Urothelial Carcinoma
06:39

Technical Modification of the Terminal Ureter During Total Transperitoneal Laparoscopic Nephroureterectomy for Upper Urinary Tract Urothelial Carcinoma

Published on: November 22, 2019

8.4K
A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

14.1K

Area of Science:

  • Oncology
  • Molecular Biology
  • Urology

Background:

  • The hepatocyte growth factor (HGF)-Met signaling pathway is implicated in tumor progression, invasion, and metastasis.
  • Met expression serves as a predictive biomarker for disease progression and survival in various cancers.
  • Met's role in urological cancers, including prostate cancer (PCa), renal cell carcinoma (RCC), and urothelial cancer, is under extensive investigation.

Purpose of the Study:

  • To review the pathological role of Met in cancer cell lines and its clinical significance in urological cancer tissues.
  • To summarize Met's predictive value in patients with urological cancers, focusing on castration-resistant PCa and different RCC subtypes.
  • To highlight the pathological significance of phosphorylated Met and summarize Met-targeted therapeutic strategies.

Main Methods:

  • Literature review of preclinical studies and clinical trials focusing on Met in urological cancers.
  • Analysis of Met expression and its correlation with clinicopathological features and patient outcomes.
  • Examination of the role of phosphorylated Met in cancer progression.
  • Summary of current and emerging Met-targeted therapies.

Main Results:

  • Met signaling is a key driver of malignant behavior in urological cancers, particularly in castration-resistant prostate cancer.
  • Distinct pathological roles of Met are observed in papillary RCC and other RCC histological types.
  • Phosphorylated Met is significantly associated with pathological progression in these cancers.
  • Met-targeted agents show potential as therapeutic strategies for urological malignancies.

Conclusions:

  • Met is a critical oncogene and a valuable predictive biomarker in urological cancers.
  • Understanding Met's specific roles in different urological cancer subtypes is essential for targeted therapy.
  • Met-targeted therapies represent a promising avenue for improving outcomes in patients with urological cancers.