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Successful treatment of relapsing autoimmune thrombotic thrombocytopenic purpura with rituximab

Senthilkumar Sankararaman1, Majed Jeroudi1, Hassan Ibrahim1

  • 1Department of Pediatrics, Louisiana State University Health Sciences Center, Shreveport, Louisiana, USA.

Pediatrics International : Official Journal of the Japan Pediatric Society
|December 19, 2014
PubMed

Thrombotic thrombocytopenic purpura (TTP) is a rare but life-threatening condition characterized by thrombotic microangiopathy. The standard treatment for TTP is plasmapheresis. For refractory or relapsing cases, various immunosuppressive agents have been tried, and among them rituximab has shown promising results. TTP is rarer in the pediatric age group and the use of rituximab in children with TTP is limited. Reported herein is the successful treatment of relapsing autoimmune TTP with rituximab in a 12-year-old girl.

Keywords:
ADAMTS13 deficiencyplasma exchangeplasmapheresisrelapserituximabthrombocytopeniathrombotic thrombocytopenic purpura

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