Related Experiment Video
Updated: Apr 19, 2026

Isolation and Cannulation of Cerebral Parenchymal Arterioles
Published on: May 23, 2016
Diffuse cerebral vasospasm with infarct after intrathecal cytarabine in childhood leukemia
Jong Hyung Yoon1, Ju Young Yoon1, Hyeon Jin Park1
1Center for Pediatric Oncology, National Cancer Center, Goyang, South Korea.
Abstract:
Although the varied neurotoxicity of intrathecal (IT) chemotherapy for treatment of childhood acute leukemia is well known, most are related to transient post-puncture headache, drug-induced arachnoiditis, or leukoencephalopathy after methotrexate or cytarabine. Cerebral vasospasm leading to acute infarct after IT chemotherapy is very uncommon in children. Reported herein is a rare case of diffuse cerebral vasospasm with subsequent cerebral infarct after IT cytarabine in a 7-year-old boy with acute lymphoblastic leukemia, who successfully recovered with supportive management, and a review of the literature.
More Related Videos
Related Concept Videos
Cerebral Edema ll: Pathophysiology
Cytotoxic Edema: Pathophysiology
Cerebral Edema l: Introduction
Drug Delivery: Parenteral Route
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
Hemorrhagic Stroke ll: Pathophysiology
Secondary Spinal Cord Injury llI: Pathophysiology

