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Extraction of Plant-based Capsules for Microencapsulation Applications
Published on: November 9, 2016
Secocrassumol, a seco-cembranoid from the Dongsha Atoll soft coral Lobophytum crassum
Shi-Yie Cheng1, Shang-Kwei Wang2, Chang-Yih Duh3
1Department of Life Sciences, National University of Kaohsiung, Kaohsiung 811, Taiwan. shiyie@nuk.edu.tw.
Abstract:
Chemical investigations on the Dongsha Atoll soft coral Lobophytum crassum led to the purification of a new seco-cembranoid, secocrassumol. The structural elucidation was established by extensive NMR, HRESIMS and CD data. The absolute configuration at C-12 was determined as S using a modified Mosher's acylation. Secocrassumol differs from previously known marine seco-cembranoid in that it possesses an unprecedented skeleton functionalized at C11-C12 bond cleavage. Secocrassumol showed antiviral activity against human cytomegalovirus (HCMV) with an IC50 value of 5.0 μg/mL.
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