[A randomized controlled study of treating chronic rhinosinusitis with macrolides].

Area of Science:

• Otolaryngology
• Pharmacology

Background:

• Chronic rhinosinusitis (CRS) is a prevalent inflammatory condition of the sinonasal mucosa.
• Effective treatment strategies for CRS, particularly refractory cases, remain a clinical challenge.

Purpose of the Study:

• To investigate the efficacy of macrolides in treating chronic rhinosinusitis.
• To evaluate the therapeutic effects of macrolides in refractory CRS cases.

Main Methods:

• A randomized controlled trial involving 165 patients with CRS.
• Patients were allocated to receive either macrolides or cephalosporins.
• Therapeutic outcomes were assessed, with a focus on macrolide effectiveness in refractory cases.

Main Results:

• No statistically significant difference was observed between the macrolides and cephalosporins groups (P > 0.05).
• Macrolide treatment showed a statistically significant improvement in patients over 3 months (P < 0.01).
• Cefixime treatment did not yield statistically significant improvements (P > 0.05).

Conclusions:

• Long-term, low-dose macrolide therapy demonstrates significant efficacy in managing chronic rhinosinusitis.
• Macrolides are particularly effective in treating refractory chronic rhinosinusitis.
• This suggests macrolides as a valuable therapeutic option for CRS management.