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Cholesterol-mediated surfactant dysfunction is mitigated by surfactant protein A

Joshua Qua Hiansen1, Eleonora Keating2, Alex Aspros1

  • 1Department of Physiology & Pharmacology, The University of Western Ontario, London, Ontario, Canada.

Biochimica Et Biophysica Acta
|December 20, 2014
PubMed
Summary

High cholesterol in pulmonary surfactant impairs lung function, especially in ventilated patients. Surfactant protein A (SP-A) can reverse this cholesterol-induced inhibition, improving lung physiology.

Keywords:
CholesterolMechanical ventilationPulmonary surfactantSP-A

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