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Updated: Jan 20, 2026

Modeling Breast Cancer in Human Breast Tissue using a Microphysiological System
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[Hydroxyproline in breast cancer].

T Iida1

  • 1Department of Surgery, Tokyo Women's Medical College, Danini Hospital, Japan.

Nihon Geka Gakkai Zasshi
|June 1, 1989
PubMed
Summary
This summary is machine-generated.

Hydroxyproline levels are elevated in breast cancer tissues compared to normal tissues. This collagen component correlates with specific cancer types, lymph node metastasis, and patient age.

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Area of Science:

  • Biochemistry
  • Oncology
  • Pathology

Context:

  • Investigated hydroxyproline content in breast cancer tissues.
  • Analyzed 40 patients with primary breast cancer.
  • Compared cancerous and noncancerous mammary gland tissues.

Purpose:

  • To determine hydroxyproline levels in breast cancer.
  • To correlate hydroxyproline content with clinicopathologic factors.

Summary:

  • Hydroxyproline levels were higher in cancerous tissue than normal mammary gland tissue.
  • Levels varied by histologic type (scirrhous carcinoma highest) and were higher with lymph node metastasis.
  • Hydroxyproline content correlated negatively with patient age and tended to be higher in advanced stages (II-IV).

Impact:

  • Provides insights into the biochemical markers of breast cancer progression.
  • Highlights hydroxyproline as a potential indicator related to tumor characteristics.
  • Suggests a link between hydroxyproline content and specific clinicopathologic features in breast cancer.