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Updated: Apr 19, 2026

Imine Metathesis by Silica-Supported Catalysts Using the Methodology of Surface Organometallic Chemistry
Published on: October 18, 2019
N-Phosphonyl/phosphinyl imines and group-assisted purification (GAP) chemistry/technology
Guanghui An1, Cole Seifert, Guigen Li
1Institute of Chemistry & BioMedical Sciences and Nanjing University, Nanjing 210093, P. R. China. guigenli@nju.edu.cn.
Abstract:
The development of environmentally benign, operationally simple, and economically viable synthetic methodologies has been a great challenge in organic synthesis. Group-assisted purification (GAP) chemistry was established to enable the synthesis of organic compounds without using traditional purification technologies, such as column chromatography and recrystallization. This concept/technology should encourage the synthetic community to make more efforts on searching for environmentally benign reagents and reactions to reduce the waste generated from silica and solvents, particularly toxic solvents; also, to reduce production/synthesis expenses, manpower, and energy. This review will discuss the GAP concept/technology and related reactions that were mainly conducted in the PI's laboratories after 2010.
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