Related Experiment Video
Updated: Apr 19, 2026

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid
Published on: April 7, 2023
Diabetes mellitus and cognitive functioning in a Serbian sample
B Salak Djokić1, M B Spitznagel, D Pavlović
1a Neurology Clinic at Clinical Center of Serbia , Belgrade , Serbia.
Type 2 diabetes (T2DM) is linked to worse cognitive function, especially in executive skills and memory. Type 1 diabetes (T1DM) showed no significant cognitive differences from healthy individuals in this Serbian study.
Area of Science:
- Neuroscience
- Endocrinology
- Psychology
Background:
- Diabetes mellitus, encompassing Type 1 (T1DM) and Type 2 (T2DM), is frequently associated with cognitive deficits.
- Impairments often manifest in executive functioning and memory domains.
Purpose of the Study:
- To investigate and compare cognitive functioning in individuals with T1DM and T2DM against healthy controls.
- The study focused on a Serbian population sample.
Main Methods:
- A neuropsychological assessment was conducted on three groups: 15 adult-onset T1DM patients, 37 T2DM patients, and 32 healthy controls.
- Participant age ranges varied across groups, with T1DM (19-60), T2DM (50-77), and controls (28-78).
Main Results:
- Type 2 diabetes patients demonstrated significantly poorer global cognitive performance, verbal learning, and memory compared to healthy controls.
- Specifically, T2DM subjects performed worse on the Trail Making Test Part B (TMT-B) after statistical correction.
- Effect sizes for T2DM versus controls were medium to large for several cognitive variables; T1DM showed minimal group differences.
Conclusions:
- Type 2 diabetes is associated with notable deficits in executive functions, learning, memory, and global cognition.
- The absence of significant cognitive differences in the Type 1 diabetes group may be attributed to the specific sample characteristics (adult-onset T1DM, relatively young T2DM cohort, or control group traits).
More Related Videos
07:41Behavioral Assessment of Visual Function via Optomotor Response and Cognitive Function via Y-Maze in Diabetic Rats
Published on: October 23, 2020
07:22Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
Published on: March 7, 2025
Related Concept Videos
Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis
Type I Diabetes III: Clinical Manifestations
Diabetes Mellitus: Type 2 and Gestational
Diabetes Mellitus: Overview and Type I Subtype
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Diabetes: Symptoms, Diagnosis, and Complications
Psychoneuroimmunology: Diabetes and Cancer