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Pyrazine derivatives: a patent review (June 2012 - present)
1Charles University in Prague, Faculty of Pharmacy in Hradec Kralove , Heyrovskeho 1203, 50005 Hradec Kralove , Czech Republic.
Expert Opinion on Therapeutic Patents
|December 20, 2014
Summary
Pyrazine derivatives show significant pharmacological effects, with recent patents highlighting their potential as anticancer and Alzheimer
Area of Science:
- Medicinal Chemistry
- Pharmacology
- Drug Discovery
Background:
- Pyrazines are 1,4-diazine heterocycles with established pharmacological importance.
- Numerous pyrazine derivatives exhibit diverse bioactivities, including antiproliferative and anti-infective properties.
- Some pyrazine derivatives are already approved drugs, underscoring their therapeutic value.
Purpose of the Study:
- To review significant patents concerning pharmacologically active pyrazine derivatives.
- To identify emerging trends and promising therapeutic applications of pyrazine compounds.
Main Methods:
- A comprehensive patent survey was conducted.
- Databases searched included SciFinder and esp@cenet.
- Focus was on patents published between June 2012 and July 2014.
Main Results:
- Pyrazine derivatives demonstrate a wide range of activities: antimycobacterial, antibacterial, antifungal, antidiabetic, diuretic, anticancer, antiviral, hypnotic, and analgesic.
- A notable increase in investigated pyrazine compounds and their biological activities was observed.
- Protein kinase inhibitors (antiproliferatives) and beta-secretase inhibitors (Alzheimer's disease) are particularly promising.
Conclusions:
- Pyrazine derivatives represent a rapidly expanding class of therapeutic agents.
- The versatility of pyrazine scaffolds supports diverse pharmacological applications.
- Future pharmaceutical development is expected to yield new pyrazine-based drugs, especially for cancer and Alzheimer's disease.
Keywords:
1,4-diazinesamiloride derivativesanticancer drugsantiprotozoal activitykinase inhibitorspyrazinamidepyrazinessodium channel blockersMore Related Videos
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