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Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

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Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
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Epigenetic Regulation01:46

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Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

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Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
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Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

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Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
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Histone Modification02:32

Histone Modification

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The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
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Related Experiment Video

Updated: Apr 19, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
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Epigenetics and lupus.

Corinne Miceli-Richard1

  • 1Université Paris-Sud, hôpitaux universitaires Paris-Sud, AP-HP, 94275 Le Kremlin-Bicêtre, France; Institut National de la santé et de la recherche médicale (Inserm) U1012, 94275 Le Kremlin-Bicêtre, France.

Joint Bone Spine
|December 20, 2014
PubMed
Summary
This summary is machine-generated.

Systemic lupus erythematosus (SLE) involves genetic and environmental factors. Epigenetic changes, like altered gene expression in T cells, contribute to SLE pathophysiology without changing DNA sequences.

Keywords:
EpigeneticsHistonesMethylationNoncoding RNAsSystemic lupus erythematosus

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Area of Science:

  • Immunology
  • Genetics
  • Molecular Biology

Background:

  • Systemic lupus erythematosus (SLE) is a complex autoimmune disease.
  • Its pathogenesis involves genetic and environmental factors.
  • Epigenetic dysregulation is implicated in SLE pathophysiology.

Purpose of the Study:

  • To review epigenetic mechanisms regulating gene expression.
  • To provide examples relevant to SLE.

Main Methods:

  • Literature review of epigenetic mechanisms.
  • Focus on DNA, histones, and noncoding RNAs.
  • Discussion of gene expression regulation in SLE.

Main Results:

  • Epigenetic modifications, such as DNA methylation and histone modifications, can alter gene expression.
  • Noncoding RNAs also play a role in epigenetic regulation.
  • These mechanisms contribute to the overexpression of genes in immune cells, like T cells, in SLE.

Conclusions:

  • Epigenetic mechanisms are crucial in the pathophysiology of SLE.
  • Understanding these mechanisms offers potential therapeutic targets.
  • Further research into epigenetics in SLE is warranted.