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Structural biology of presenilin 1 complexes

Yi Li, Christopher Bohm, Roger Dodd

  • 1Cambridge Institute for Medical Research, Wellcome Trust MRC Building, Addenbrookes Hospital, Hills Road, Cambridge CB2 0XY, UK. p.hyslop@utoronto.ca.

Molecular Neurodegeneration
|December 20, 2014
PubMed
Summary

Presenilin proteins form the gamma-secretase complex, crucial for Alzheimer's disease. Structural insights reveal allosteric gating mechanisms controlling substrate access and cleavage, aiding drug development.

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