Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Taurine Boosts Cellular Uptake of Small D-Peptides for Enzyme-Instructed Intracellular Molecular Self-Assembly.

Journal of the American Chemical Society·2015
Same author

Diameter-Axial-Polar Nephrometry is Predictive of Surgical Outcomes Following Partial Nephrectomy.

Medicine·2015
Same author

Assessing visual green effects of individual urban trees using airborne Lidar data.

The Science of the total environment·2015
Same author

A New Ligustrazine Derivative-Selective Cytotoxicity by Suppression of NF-κB/p65 and COX-2 Expression on Human Hepatoma Cells. Part 3.

International journal of molecular sciences·2015
Same author

Organ and effective dose evaluation in coronary angiography by using a 320 MDCT based on in-phantom dose measurements with TLDs.

Journal of radiological protection : official journal of the Society for Radiological Protection·2015
Same author

High Strength Multifunctional Multiwalled Hydrogel Tubes: Ion-Triggered Shape Memory, Antibacterial, and Anti-inflammatory Efficacies.

ACS applied materials & interfaces·2015
Same journal

Synthesis of covalent organic frameworks and plasmon-assisted exfoliation for enhanced solar hydrogen production.

Journal of colloid and interface science·2026
Same journal

Efficient hydrogen production and anti-coking via reforming of waste plastics by oxygen vacancy promoted plasma-catalysis.

Journal of colloid and interface science·2026
Same journal

Lanthanum-modulated hollow CuO nanofibers enable selective CO<sub>2</sub> electroreduction to multicarbon products at high current densities.

Journal of colloid and interface science·2026
Same journal

Tris(vinyl dimethylsilyl) phosphate: Enhancing interface stability in high-voltage Li-ion batteries at elevated temperatures.

Journal of colloid and interface science·2026
Same journal

Electron-donor modulated built-in electric fields in Ni<sub>2</sub>P/MoS<sub>2</sub> Heterostructures for accelerated sodium storage kinetics.

Journal of colloid and interface science·2026
Same journal

Porous flexible structure mediated synergistic boost of built-in electric field and photothermal effect for enhanced photocatalysis.

Journal of colloid and interface science·2026
See all related articles

Related Experiment Video

Updated: Apr 19, 2026

Synthesis of an Intein-mediated Artificial Protein Hydrogel
15:06

Synthesis of an Intein-mediated Artificial Protein Hydrogel

Published on: January 27, 2014

12.8K

The first CD73-instructed supramolecular hydrogel.

Dongdong Wu1, Xuewen Du1, Junfeng Shi1

  • 1Department of Chemistry, Brandeis University, 415 South St., Waltham, MA 02454, USA.

Journal of Colloid and Interface Science
|December 20, 2014
PubMed
Summary
This summary is machine-generated.

Researchers discovered that the ectoenzyme CD73 can trigger hydrogel formation through self-assembly. This finding offers new possibilities for developing CD73-based materials and therapies for cancer.

Keywords:
AMPCD73EnzymeHydrogel

More Related Videos

Easy Manipulation of Architectures in Protein-based Hydrogels for Cell Culture Applications
08:50

Easy Manipulation of Architectures in Protein-based Hydrogels for Cell Culture Applications

Published on: August 4, 2017

7.3K
Microwave-assisted Functionalization of Polyethylene glycol and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation
15:33

Microwave-assisted Functionalization of Polyethylene glycol and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation

Published on: October 29, 2013

30.0K

Related Experiment Videos

Last Updated: Apr 19, 2026

Synthesis of an Intein-mediated Artificial Protein Hydrogel
15:06

Synthesis of an Intein-mediated Artificial Protein Hydrogel

Published on: January 27, 2014

12.8K
Easy Manipulation of Architectures in Protein-based Hydrogels for Cell Culture Applications
08:50

Easy Manipulation of Architectures in Protein-based Hydrogels for Cell Culture Applications

Published on: August 4, 2017

7.3K
Microwave-assisted Functionalization of Polyethylene glycol and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation
15:33

Microwave-assisted Functionalization of Polyethylene glycol and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation

Published on: October 29, 2013

30.0K

Area of Science:

  • Biomaterials Science
  • Enzymology
  • Supramolecular Chemistry

Background:

  • Enzymatic supramolecular hydrogelation is a novel strategy for creating soft colloidal materials.
  • Integrating self-assembly with enzyme-driven biological processes is key for developing advanced materials.
  • There is a need for new enzymes that can participate in hydrogelation to create useful soft colloids.

Purpose of the Study:

  • To explore the potential of ectoenzymes in hydrogelation.
  • To investigate the use of CD73 in self-assembly and hydrogel formation.
  • To establish new strategies for CD73-guided materials and therapies.

Main Methods:

  • Investigated the hydrogelation properties of the ectoenzyme CD73.
  • Utilized CD73's enzymatic activity to trigger the formation of nanofibers.
  • Characterized the resulting hydrogel matrices.

Main Results:

  • CD73 was identified as an enzyme capable of triggering hydrogel formation.
  • CD73 self-assembly resulted in the formation of nanofiber matrices.
  • The study demonstrated the successful application of CD73 in hydrogelation.

Conclusions:

  • CD73 can be effectively employed in self-assembly and hydrogelation processes.
  • This work presents a new method for creating hydrogels using CD73.
  • The findings suggest potential new strategies for CD73-based materials and cancer therapies.