Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Hypothyroidism II: Pathophysiology

Hypothyroidism II: Pathophysiology

Hypothyroidism is a disorder characterized by insufficient production of thyroid hormones, which regulate metabolism, energy balance, and multiple organ systems.TypesHypothyroidism is classified based on the level of dysfunction. Primary hypothyroidism results from intrinsic thyroid gland dysfunction, causing reduced hormone production despite normal or increased stimulation. Secondary hypothyroidism arises from inadequate thyroid-stimulating hormone (TSH) secretion by the pituitary. Tertiary...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Developmental timing of repeated dexamethasone exposure determines growth and modulates metabolic responsiveness in adulthood.

Biochemical pharmacology·2026

Same author

Digested galactoglucomannan mitigates oxidative stress in human cells, restores gut bacterial diversity, and provides chemopreventive protection against colon cancer in rats.

International journal of biological macromolecules·2024

Same author

Synthesis and pharmacological evaluation of novel N-aryl-cinnamoyl-hydrazone hybrids designed as neuroprotective agents for the treatment of Parkinson's disease.

Bioorganic chemistry·2024

Same author

Peripheral inflammatory hyperalgesia is exacerbated in rats with metabolic disorders induced by a fructose diet.

Physiology international·2024

Same author

Psychedelic 25H-NBOMe attenuates post-sepsis depression in rats.

Neuroscience letters·2024

Same author

Neuromodulator hydrogen sulfide attenuates sickness behavior induced by lipopolysaccharide.

Journal of neuroimmunology·2024

Search research articles

Related Experiment Video

Updated: Apr 19, 2026

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

Sickness behavior is delayed in hypothyroid mice.

Vanessa Cardoso Silva¹, Alexandre Giusti-Paiva²

¹Programa Multicêntrico de Pós-Graduação em Ciências Fisiológicas, Sociedade Brasileira de Fisiologia (SBFis), Brazil; Universidade Federal de Juiz de Fora, Campus Governador Valadares, Minas Gerais, Brazil.

Brain, Behavior, and Immunity

|December 20, 2014

Summary

Thyroid status modulates sickness behavior in mice. Hypothyroidism delayed behavioral changes following an immune challenge, indicating thyroid hormones are essential for sickness responses during endotoxemia.

Keywords:

Anorexia Endotoxemia Fever Hypothyroidism Sickness behavior

More Related Videos

Author Spotlight: Accurately Assessing Thyroid Hormone-Driven Motor Alterations in Mouse

Author Spotlight: Accurately Assessing Thyroid Hormone-Driven Motor Alterations in Mouse

Published on: October 6, 2023

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model

Published on: October 6, 2023

Related Experiment Videos

Last Updated: Apr 19, 2026

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

Author Spotlight: Accurately Assessing Thyroid Hormone-Driven Motor Alterations in Mouse

Author Spotlight: Accurately Assessing Thyroid Hormone-Driven Motor Alterations in Mouse

Published on: October 6, 2023

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model

Published on: October 6, 2023

Area of Science:

Neuroimmunology
Endocrinology
Behavioral Science

Background:

Sickness behavior is a motivational state driven by the immune system to combat infection.
The interplay between thyroid hormones, the central nervous system, and immune function in sickness behavior requires further investigation.
Thyroid hormones play a complex role in immune cell function.

Purpose of the Study:

To investigate the impact of hypothyroidism on sickness behavior in mice.
To understand how thyroid status influences behavioral responses to an immunological challenge.

Main Methods:

Mice were rendered hypothyroid using propylthiouracil (PTU) for 30 days.
Hypothyroid and control mice received an intraperitoneal injection of lipopolysaccharide (LPS) or saline.
Behavioral responses, including depressive-like and exploratory behaviors, were assessed over 24 hours using open field and forced swimming tests.

Main Results:

Propylthiouracil (PTU) pretreatment delayed the onset of lipopolysaccharide (LPS)-induced behavioral changes in hypothyroid mice.
Hypothyroid mice exhibited delayed depressive-like and exploratory behavior alterations following LPS administration.
A lower thermal index was observed in hypothyroid mice up to 4 hours after LPS injection.

Conclusions:

Thyroid status significantly modulates sickness behavior in response to immune challenges like endotoxemia.
Thyroid hormones are crucial for the full manifestation of sickness behavior during immune activation.
These findings highlight the importance of thyroid hormone regulation in neuroimmune interactions.