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Adenocarcinomas of appendix: a rare tumor. Two case reports
V Romeo1, M Farina1, S Petrangeli1
1UOC Chirurgia I. Azienda Ospedaliera San Giovanni-Addolorata, Rome, Italy.
La Clinica Terapeutica
|December 20, 2014
Summary
Primary appendiceal adenocarcinoma, a rare cancer, is often misdiagnosed as appendicitis. Early diagnosis and tailored surgical treatment, including cytoreductive surgery and hyperthermic chemotherapy for advanced cases, are crucial.
Area of Science:
- Gastroenterology and Oncology
- Surgical Pathology
Background:
- Primary appendiceal adenocarcinomas are rare neoplasms.
- Diagnosis is frequently incidental, discovered post-appendectomy for suspected acute appendicitis.
- Preoperative diagnostic accuracy of laboratory exams and imaging is limited.
Observation:
- Two cases of primary mucinous adenocarcinoma of the appendix in Caucasian men are presented.
- Initial presentation mimicked acute appendicitis, leading to appendectomy.
- Histopathological examination confirmed mucinous adenocarcinoma.
Findings:
- Appendiceal mucinous adenocarcinoma requires tailored surgical management based on stage and presentation.
- Advanced cases benefit from cytoreductive surgery combined with Intraoperative Hyperthermic Chemotherapy (IOHC).
Implications:
- Highlights the challenge in preoperative diagnosis of appendiceal adenocarcinoma.
- Emphasizes the importance of histopathological examination for definitive diagnosis.
- Underscores the efficacy of cytoreductive surgery and IOHC in managing advanced appendiceal neoplasms.
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