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A Laboratory Method to Measure Contagious Yawning in Rats
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Yaws.

Michael Marks1, Oriol Mitjà2, Anthony W Solomon3

  • 1Clinical Research Department, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK Hospital for Tropical Diseases, University College London Hospitals NHS Trust, Mortimer Market, London WC1E 6JB, UK michael.marks@lshtm.ac.uk.

British Medical Bulletin
|December 20, 2014
PubMed
Summary
This summary is machine-generated.

Yaws eradication is an achievable goal with mass treatment using azithromycin. Ongoing studies will refine strategies for global yaws elimination and integrate diagnostics.

Keywords:
eradicationneglected tropical diseasessyphilisyaws

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Area of Science:

  • Neglected Tropical Diseases
  • Infectious Disease Epidemiology

Background:

  • Yaws, caused by Treponema pallidum ssp. pertenue, is a tropical infectious disease endemic in parts of West Africa, Southeast Asia, and the Pacific.
  • The World Health Organization (WHO) initiated a campaign for yaws eradication by 2020, utilizing mass treatment with azithromycin.

Purpose of the Study:

  • To review the current status and strategies for yaws eradication.
  • To identify areas of agreement and controversy in yaws control efforts.

Main Methods:

  • A comprehensive review of published literature, surveillance data, and yaws eradication meeting proceedings.
  • Analysis of data from 76 countries that have previously reported yaws cases.

Main Results:

  • Azithromycin is established as the primary treatment for yaws, with point-of-care tests proving valuable for diagnosis.
  • Limited data exists for many endemic countries, and varying azithromycin dosages are employed in mass treatment programs for yaws and trachoma.

Conclusions:

  • Yaws eradication is a feasible objective, contingent upon substantial support from health and development partners.
  • Further research is crucial for baseline mapping, integrating diagnostics into surveillance, and evaluating the impact of mass azithromycin treatment.