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Published on: August 1, 2025
Pancreatic mass leading to left-sided portal hypertension, causing bleeding from isolated gastric varices
Helga Thrainsdottir1, Vigdis Petursdottir2, Sigurdur Blöndal3
1Section of Gastroenterology, Department of Internal Medicine, The National University Hospital of Iceland, Hringbraut, 101 Reykjavik, Iceland ; Faculty of Medicine, University of Iceland, Vatnsmyrarvegur 16, 101 Reykjavik, Iceland.
Abstract:
Mucinous cystic neoplasms (MCN) are an uncommon form of exocrine neoplasms of the pancreas. Symptoms are most often vague and this makes the diagnosis more difficult. The current case is one of three cases yet reported where the MCN caused left-sided portal hypertension leading to the formation of isolated gastric varices and subsequent bleeding from the varices. In the previously reported cases the main symptom was hematemesis. However in the current case the patient experienced no hematemesis, only isolated incidents of dark coloured diarrhea, but the main symptoms were those of iron-deficiency anemia. We present the case report of a 34-year-old woman who presented with dizziness and lethargy and was found to have 12 cm MCN in the pancreas.
Insights
Mucinous cystic neoplasms (MCNs) can cause rare complications like left-sided portal hypertension, leading to gastric varices. This case highlights unusual symptoms of iron-deficiency anemia instead of typical bleeding in MCN patients.
Area of Science:
- Gastroenterology
- Oncology
- Surgical Pathology
Background:
- Mucinous cystic neoplasms (MCNs) are rare pancreatic exocrine tumors.
- Vague symptoms often delay MCN diagnosis.
- Complications like portal hypertension are infrequently reported.
Purpose of the Study:
- To report a rare case of MCN causing left-sided portal hypertension.
- To highlight unusual clinical presentations of MCN.
- To discuss the diagnostic challenges and management of MCN complications.
Main Methods:
- Case report of a 34-year-old woman.
- Clinical presentation with dizziness and lethargy.
- Imaging revealed a 12 cm pancreatic MCN.
Main Results:
- The MCN caused left-sided portal hypertension.
- This led to isolated gastric varices and bleeding.
- The patient presented with iron-deficiency anemia, not hematemesis.
Conclusions:
- MCNs can present with atypical symptoms, including iron-deficiency anemia.
- Left-sided portal hypertension is a rare but serious complication of MCN.
- Early diagnosis and management are crucial for favorable outcomes.
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