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Related Experiment Video

Updated: Apr 19, 2026

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
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Current knowledge and future prospects for SAPHO syndrome.

C Kim1

  • 1West Virginia University, Department of Neurosurgery, Morgantown, West Virginia, USA. kimc@wvuhealthcare.com.

Drugs of Today (Barcelona, Spain : 1998)
|December 20, 2014
PubMed
Summary
This summary is machine-generated.

Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome presents with bone and skin issues. Current treatments include NSAIDs, DMARDs, and emerging TNF inhibitors showing promise.

Keywords:
Analgesic drugsDermatologic drugsPainTreatment of autoimmune diseaseTreatment of musculoskeletal and connective tissue diseases

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Area of Science:

  • Rheumatology
  • Dermatology
  • Orthopedics

Background:

  • SAPHO syndrome is a complex disorder with osteoarticular and cutaneous manifestations.
  • Key symptoms include bone pain and various dermatologic conditions.
  • Diagnosis relies on excluding infections and identifying characteristic bone changes.

Purpose of the Study:

  • To review the current understanding of SAPHO syndrome.
  • To discuss the evolving treatment landscape for SAPHO syndrome.

Main Methods:

  • Literature review of SAPHO syndrome pathophysiology and treatments.
  • Analysis of existing therapeutic options and emerging therapies.

Main Results:

  • Pathophysiology remains unclear, with multiple hypotheses proposed.
  • A wide range of medications, including NSAIDs and DMARDs, have been utilized.
  • Tumor necrosis factor inhibitors represent a promising new therapeutic avenue.

Conclusions:

  • SAPHO syndrome requires a multidisciplinary approach.
  • Advances in understanding are driving the development of more effective treatments, notably TNF inhibitors.