Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

88.6K
Overview
88.6K
Tissue Transplantation01:24

Tissue Transplantation

1.3K
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
1.3K
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

2.8K
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
2.8K
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

10.3K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
10.3K
Immunological Memory01:23

Immunological Memory

18.1K
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
18.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Autoreactive antibody production by intrarenal B cells in mouse kidney allograft rejection.

bioRxiv : the preprint server for biology·2026
Same author

Reversing pregnancy-induced B cell sensitization to facilitate the induction of transplant tolerance in postpartum recipients.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2026
Same author

Topography of B-cell Immunodominance.

Transplantation·2026
Same author

APOL1-risk alleles modulate T-cell receptor signaling to promote allograft rejection.

The Journal of clinical investigation·2026
Same author

Dual induction of tissue-resident T and B cell immunity for broad influenza protection with a nanofiber-VLP vaccine.

Journal of nanobiotechnology·2026
Same author

High-dimensional spatial proteomics and novel machine learning pipeline identifies disease specific renal damage states.

bioRxiv : the preprint server for biology·2026
Same journal

Filtered or Fried? Rethinking Intraoperative Cell Salvage in Liver Transplantation.

Transplantation·2026
Same journal

Simultaneous Liver-kidney Versus Liver Transplantation Categorized by Pretransplant eGFR: Impact of the 2017 OPTN Policy.

Transplantation·2026
Same journal

Preformed Anti-DQ Alpha Donor-specific Antibodies and the Risk of Antibody-mediated Rejection After Kidney Transplantation.

Transplantation·2026
Same journal

People in Transplantation: Professor Nadey Hakim, MD, PhD, FRCS, FRCSGlas (Hon), FACS, President-Elect of The Transplantation Society.

Transplantation·2026
Same journal

IL-1 Receptor Blockade Modulates Inflammation During Sequential Perfusion in Ex Vivo Porcine Kidneys.

Transplantation·2026
Same journal

Regulatory T Cells Allosensitized Under the Blockade of CD80/CD86-CD28 Costimulation Prolonged Islet Allograft Survival.

Transplantation·2026
See all related articles

Related Experiment Video

Updated: Apr 19, 2026

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
18:48

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

15.0K

Memory B cells in transplantation.

Anita S Chong1, Roger Sciammas

  • 11 Department of Surgery, The University of Chicago, Chicago, IL. 2 Transplant Immunobiology Center, Houston Methodist Research Institute, Houston, TX.

Transplantation
|December 20, 2014
PubMed
Summary
This summary is machine-generated.

New technologies enable the study of memory B cells in transplantation. Understanding these cells is crucial for improving graft and patient survival by examining both alloreactive and pathogen-specific responses.

More Related Videos

Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease
08:05

Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease

Published on: March 17, 2020

8.5K
Stereotactic Adoptive Transfer of Cytotoxic Immune Cells in Murine Models of Orthotopic Human Glioblastoma Multiforme Xenografts
11:15

Stereotactic Adoptive Transfer of Cytotoxic Immune Cells in Murine Models of Orthotopic Human Glioblastoma Multiforme Xenografts

Published on: September 1, 2018

8.6K

Related Experiment Videos

Last Updated: Apr 19, 2026

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
18:48

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

15.0K
Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease
08:05

Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease

Published on: March 17, 2020

8.5K
Stereotactic Adoptive Transfer of Cytotoxic Immune Cells in Murine Models of Orthotopic Human Glioblastoma Multiforme Xenografts
11:15

Stereotactic Adoptive Transfer of Cytotoxic Immune Cells in Murine Models of Orthotopic Human Glioblastoma Multiforme Xenografts

Published on: September 1, 2018

8.6K

Area of Science:

  • Immunology
  • Transplant Science
  • Cellular Biology

Background:

  • Humoral immune responses to allografts traditionally focus on antibodies and plasma cells.
  • The memory B cell compartment remains understudied due to technical challenges in its analysis.
  • Memory B cells play a critical role in long-term transplant success and pathogen defense.

Purpose of the Study:

  • To review emerging technologies for identifying and characterizing memory B cells.
  • To explore the heterogeneity and function of memory B cells in experimental models and transplant recipients.
  • To investigate the impact of immunosuppression on allospecific and pathogen-specific memory B cells for improved transplant outcomes.

Main Methods:

  • Utilizing novel technologies to identify quiescent and responsive memory B cells.
  • Analyzing memory B cell phenotype, function, and antibody production in experimental models.
  • Applying similar techniques to identify memory B cells in human transplant recipients.

Main Results:

  • New technologies reveal insights into memory B cell heterogeneity and function.
  • Comparable memory alloreactive B cells are identifiable in transplant patients.
  • The study highlights the importance of both allospecific and pathogen-specific memory B cells.

Conclusions:

  • Emerging technologies facilitate the comprehensive study of memory B cells in transplantation.
  • Understanding memory B cell dynamics under immunosuppression is key to enhancing graft and patient survival.
  • Future research can leverage these techniques to optimize transplant protocols and patient care.