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Early Detection of Drug-Induced Renal Hemodynamic Dysfunction Using Sonographic Technology in Rats
Published on: March 11, 2016
The identification of three novel biomarkers of major adverse kidney events
Michael Haase1, Rinaldo Bellomo, Christian Albert
1Department of Nephrology & Hypertension, Diabetes & Endocrinology Otto-von-Guericke University, Magdeburg, Germany.
Aim:
To describe the prognostic value of three novel biomarkers for acute adverse kidney events compared with routine biological markers.
Material & Methods:
We used high-end MS to quantify biomarkers predictive of acute kidney injury (AKI) and major adverse kidney events (MAKE) in 100 adult patients after open heart surgery (n = 100).
Results:
Early postoperatively measured LG3 (a C-terminal fragment of perlecan), LTBP2 (latent transforming growth factor binding protein-2), Cathepsin L as well as two other renal biomarkers (NGAL, Cystatin C) had greater predictive value for AKI (n = 23) and MAKE (n = 24) compared with creatinine, urea and urine output.
Conclusions:
LG3, LTBP2 and Cathepsin L deserve further exploration as biomarkers for the early identification of patients at risk of MAKE.
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