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Pregnenolone functions in centriole cohesion during mitosis

Mayumi Hamasaki1, Shigeru Matsumura1, Ayaka Satou2

  • 1Department of Cell Biology, Institute for Virus Research, Kyoto University, Sakyo-ku, Kyoto 606-8507, Japan; Department of Cell and Developmental Biology, Graduate School of Biostudies, Kyoto University, Sakyo-ku, Kyoto 606-8502, Japan.

Chemistry & Biology
|December 20, 2014
PubMed
Summary

Pregnenolone (P5), a cholesterol-derived steroid, is crucial for maintaining centriole cohesion during cell division. This metabolite directly binds to shugoshin 1, preventing premature centriole separation and ensuring proper spindle formation.

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