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Exogenous ochronosis.

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Exogenous ochronosis can occur in any skin type, even with low concentrations of hydroquinone. Awareness is crucial for clinicians and patients to prevent this rare side effect.

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Area of Science:

  • Dermatology
  • Toxicology

Background:

  • Exogenous ochronosis is a rare skin condition.
  • Traditionally associated with darker skin types and high-concentration hydroquinone use.

Observation:

  • A case of exogenous ochronosis in a 53-year-old woman with skin type IV.
  • Prolonged use of a topical hydroquinone preparation of unknown concentration.

Findings:

  • Exogenous ochronosis is increasingly reported across all skin types.
  • Cases occur even with low-concentration hydroquinone and shorter durations.

Implications:

  • Clinicians and patients must be aware of this side effect.
  • Early recognition can prevent exacerbation.
  • The incidence in the US may be underestimated.