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Adipo-Clear: A Tissue Clearing Method for Three-Dimensional Imaging of Adipose Tissue

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Adiposis dolorosa.

Panta Rouhani Schaffer¹, Christopher S Hale, Shane A Meehan

¹New York University School of Medicine.

Dermatology Online Journal

|December 20, 2014

Summary

This summary is machine-generated.

Adiposis dolorosa (Dercum's disease) is a rare disorder characterized by painful fatty tissue deposits. This case highlights the chronic pain and systemic symptoms associated with the condition.

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Area of Science:

Endocrinology
Dermatology
Pain Medicine

Background:

Adiposis dolorosa, or Dercum's disease, is a rare disorder characterized by lipomas and chronic pain.
It primarily affects middle-aged women and can present with systemic symptoms impacting quality of life.

Observation:

A 46-year-old woman presented with a nine-year history of obesity, chronic diffuse pain in adipose tissue (arms, trunk, thighs), and multiple lipomas.
Systemic symptoms included generalized weakness, fatigue, memory impairment, and arthralgias.
Some lesions were tender, while others were only palpable.

Findings:

Clinical history and histopathologic findings were consistent with adiposis dolorosa (Dercum's disease).
The patient exhibited multiple biopsy-proven lipomas and angiolipomas, along with a breast lipomatous pseudomass.

Implications:

This case underscores the importance of recognizing adiposis dolorosa in patients with unexplained chronic pain and lipomas.
An interdisciplinary approach involving analgesics and doxycycline was initiated to manage the chronic pain.
Further research into the pathophysiology and treatment of Dercum's disease is warranted.