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Imaging of gliomas at 1.5 and 3 Tesla - A comparative study

Lambros Tselikas1, Raphaëlle Souillard-Scemama1, Olivier Naggara1

  • 1Neuroimaging Department, Centre Hospitalier Sainte-Anne, Paris, France (L.T., R.S.-S., O.N., C.M., J.-F.M., C.O.); Neurosurgery Department, Centre Hospitalier Sainte-Anne, Paris, France (E.D., B.D., J.P.); Neuropathology Department, Centre Hospitalier Sainte-Anne, Paris, France (P.V., F.C.); INSERM U 894 Centre Hospitalier Sainte-Anne, Paris, France (O.N., C.O.); Radiation Therapy and Physics Department, Gustave Roussy Institute, Villejuif, France (F.D.); Medical Oncology department, Gustave Roussy Institute, Villejuif, France (J.D.); Université Paris Descartes, Paris, France (O.N., P.V., F.C., J.-F.M., J.P., C.O.).

Neuro-Oncology
|December 21, 2014
PubMed
Abstract

Insights

Magnetic resonance imaging (MRI) at 1.5 Tesla (T) and 3T provide comparable data for tracking glioma progression. This allows for flexible monitoring of patients with WHO grades II and III gliomas, regardless of the MRI scanner strength used.

Area of Science:

  • Radiology
  • Neuro-oncology
  • Medical Imaging

Background:

  • Glioma follow-up relies on MRI parameters correlated with patient survival.
  • Established criteria for tumor response evaluation may be affected by variations in MRI instrumentation, such as magnetic field strength.
  • This study investigates the comparability of MRI information obtained at 3 Tesla (T) and 1.5T.

Purpose of the Study:

  • To assess whether MRI scans acquired at 1.5T and 3T yield similar information for glioma follow-up.
  • To compare key imaging features between 1.5T and 3T MRI in patients with gliomas.
  • To determine the concordance of quantitative and qualitative MRI metrics between different magnetic field strengths.

Main Methods:

  • Retrospective comparison of MRI features in 30 patients with WHO grades II and III gliomas.
  • Patients underwent both 1.5T and 3T MRI within one month, with no clinical changes.
  • Comparison of lesion volumes (FLAIR), ratio of cerebral blood volume (rCBV), and contrast-to-noise ratio (CNR) using intraclass correlation coefficient (ICC) and weighted-kappa (wκ).

Main Results:

  • Interobserver and intraobserver concordance for lesion volume was nearly perfect for both 1.5T (ICC=0.96/0.97) and 3T (ICC=0.99/0.98).
  • Agreement for contrast enhancement was excellent at both 1.5T and 3T (wκ=0.92).
  • Correlations for lesion volume (ICC=0.97) and rCBV (ICC=0.92) between modalities were nearly perfect.

Conclusions:

  • 1.5T and 3T MRI provide similar imaging features for monitoring WHO grades II and III gliomas.
  • Glioma monitoring can be reliably performed using either 1.5T or 3T MRI scanners.
  • The magnetic field strength does not significantly impact the comparability of key imaging parameters for glioma follow-up.
Keywords:
MRIgliomaneuroimagingobserver variationreproducibility of results

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