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Published on: July 26, 2024
α-Glucosidase inhibitors from the leaves of Embelia ribes
Phu Hoang Dang1, Nhan Trung Nguyen1, Hai Xuan Nguyen1
1Faculty of Chemistry, University of Science, Vietnam National University, Hochiminh City, 227 Nguyen Van Cu Street, District 5, HoChiMinh City, Vietnam.
Abstract:
A novel and rare 1,4-dehydrated ceramide, embelamide (1), and a new C-glycoalkaloid which is based on a β-carboline ring system, 1-(2'-deoxy-α-d-ribopyranosyl)-β-carboline (4), were isolated from the CHCl3 soluble fraction of the leaves of Embelia ribes (Myrsinaceae), together with thirteen known compounds (2-3, 5-15). Their structures were elucidated on the basis of spectroscopic data. Compounds 1, and 5-12 possessed significant α-glucosidase inhibitory activity in a concentration-dependent manner, and showed more potent inhibitory activity, with IC50 values ranging from 1.3 to 155.0 μM, than that of a positive control acarbose (IC50, 214.5 μM).
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