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Related Experiment Video

Updated: Apr 19, 2026

Hippocampal Insulin Microinjection and In vivo Microdialysis During Spatial Memory Testing
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Glucose, relational memory, and the hippocampus.

Brian Stollery1, Leonie Christian

  • 1School of Experimental Psychology, University of Bristol, Bristol, UK, Brian.Stollery@Bristol.ac.uk.

Psychopharmacology
|December 21, 2014
PubMed
Summary

Glucose administration before learning may reduce forgetting, while glucose during retrieval improves memory recall. These effects were observed in verbal paired associate tasks, impacting both high and low imagability word pairs.

Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Metabolism

Background:

  • Glucose is known to temporarily enhance hippocampal-dependent memory formation.
  • The hippocampus is crucial for associative learning, including verbal paired associate memory.

Purpose of the Study:

  • To investigate how glucose affects performance in a relational memory task.
  • To examine glucose's influence on learning, subsequent forgetting, and relearning of verbal paired associates.

Main Methods:

  • 80 participants were tested twice using a selective reminding procedure with high and low imagability paired associates.
  • Glucose (25g) or placebo was administered pre-learning, post-learning, or during retrieval sessions.
  • Cued-recall was assessed after learning, after a one-week delay (forgetting), and after relearning.

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Related Experiment Videos

Last Updated: Apr 19, 2026

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Main Results:

  • Glucose did not impact initial paired associate acquisition.
  • Pre-learning glucose administration showed a trend towards reduced forgetting over one week.
  • Glucose during delayed retrieval significantly improved cued-recall performance.
  • Both effects were consistent across high and low imagability pairs.

Conclusions:

  • Glucose administration during encoding may enhance the initial availability of memories.
  • Glucose during retrieval appears to increase the accessibility of existing memories.
  • These findings suggest distinct roles for glucose in memory consolidation and retrieval processes, potentially mediated by hippocampal mechanisms.