Related Experiment Video
Updated: Apr 19, 2026
02:28
Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
Published on: March 1, 2024
1.0K
Relapsing polychondritis: clinical presentations, disease activity and outcomes
Aman Sharma1, Arjun Dutt Law2, Pradeep Bambery3
1Department of Internal Medicine, Postgraduate Institute of medical education and research, Chandigarh, India. amansharma74@yahoo.com.
Orphanet Journal of Rare Diseases
|December 21, 2014
Summary
Relapsing polychondritis (RP) in India presents similarly to global patterns, with auricular chondritis and arthritis being common. This study offers insights into RP patient experiences in a North Indian tertiary center.
Area of Science:
- Rheumatology
- Immunology
- Rare Diseases
Background:
- Relapsing polychondritis (RP) is a rare systemic autoimmune disease characterized by progressive inflammation of cartilaginous tissues.
- Limited single-center case series exist globally, necessitating further research into regional disease characteristics.
Observation:
- This study retrospectively analyzed 26 patients diagnosed with relapsing polychondritis (RP) at a tertiary care center in North India.
- Patients met Damiani and Levine's modification of McAdam's diagnostic criteria.
- Data collected included clinical manifestations, disease activity (RPDAI), treatments, and outcomes.
Findings:
- The cohort comprised 10 males and 16 females with a median age of 45 years.
- Common manifestations included auricular chondritis (96%), arthritis (54%), hearing impairment (42%), ocular (42%), and dermal involvement (26%).
- Cardiovascular and laryngotracheal involvement were observed in 11% of patients. Median RPDAI was 31, with an overall survival rate of 92.3% over a median of 13.5 years.
Implications:
- Relapsing polychondritis (RP) in India shares clinical similarities with international cohorts, except for a potentially lower incidence of laryngotracheal involvement.
- Findings contribute to understanding the epidemiology and clinical spectrum of RP in the Indian subcontinent.
- This data can inform clinical management and future research directions for relapsing polychondritis (RP).
Related Concept Videos
01:22Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
1.2K
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
1.2K
01:19Chronic Obstructive Pulmonary Disease IV: Clinical Manifestations
20
Chronic Obstructive Pulmonary Disease, or COPD, is a long-term condition marked by persistent and only partially reversible airflow limitation. It involves two overlapping conditions—chronic bronchitis and emphysema—which often co-appear but differ in dominant symptoms and underlying mechanisms.Chronic Bronchitis FeaturesChronic bronchitis presents with a persistent productive cough and thick, sometimes purulent mucus due to airway inflammation, enlarged mucus glands, and goblet...
20
01:20COPD: Pathogenesis and Clinical Features
2.3K
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
2.3K
01:19Pericarditis II: Clinical Features and Diagnostic Tests
594
Pericarditis is distinguished by inflammation of the pericardium, the fibrous sac that encases the heart. It can be acute, lasting less than six weeks, or chronic, persisting for over three months. Understanding its clinical manifestations and diagnostic findings is crucial for timely and effective management.Clinical ManifestationsWhile pericarditis can be asymptomatic, it usually presents with characteristic symptoms such as:Chest Pain: The most characteristic symptom of pericarditis is chest...
594
01:20Inflammatory Bowel Disease IV: Clinical Manifestations
16
Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The...
16
01:25Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.
4.2K
Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
4.2K