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Related Experiment Video

Updated: Apr 19, 2026

Measuring Local Anaphylaxis in Mice

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Published on: October 14, 2014

Hereditary Angioedema Attacks: Local Swelling at Multiple Sites.

Zonne L M Hofman¹, Anurag Relan², C Erik Hack³

¹Laboratory for Translational Immunology, University Medical Center Utrecht, Lundlaan 6, P.O. Box 85090, 3508, GA, Utrecht, The Netherlands. zonnehofman@gmail.com.

Clinical Reviews in Allergy & Immunology

|December 21, 2014

Summary

This summary is machine-generated.

Hereditary angioedema (HAE) attacks often involve multiple body parts simultaneously, challenging the view of HAE as a localized condition. This suggests HAE symptoms may stem from a systemic process, not just local inflammation.

Keywords:

C1-inhibitor deficiency Hereditary angioedema

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Area of Science:

Immunology
Genetics
Clinical Medicine

Background:

Hereditary angioedema (HAE) causes recurrent swelling, potentially life-threatening.
Most HAE research focuses on single-site attacks, overlooking multi-location events.

Purpose of the Study:

To investigate the frequency, severity, and clinical course of HAE attacks involving multiple anatomical locations.
To better understand the systemic nature of HAE.

Main Methods:

Analysis of 219 HAE attacks in 119 patients from recombinant human C1-inhibitor (rhC1INH) studies.
Evaluation of patient-reported visual analog scale (VAS) scores and investigator symptom scores.

Main Results:

28% of patients experienced multi-location HAE attacks, with up to five simultaneous sites.
Severe HAE attacks frequently involved multiple, anatomically unrelated body regions.

Conclusions:

HAE attacks commonly affect multiple body sites concurrently.
Findings suggest HAE is a systemic condition, contrary to the prevailing local process theory.