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S-Nitrosylation in neurogenesis and neuronal development
Shu-ichi Okamoto1, Stuart A Lipton1
1Neuroscience and Aging Research Center, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA; Department of Neurosciences, University of California San Diego, School of Medicine, 9500 Gilman Drive, La Jolla, CA, USA.
Biochimica Et Biophysica Acta
|December 22, 2014
Summary
Nitric oxide (NO) S-nitrosylation is key for neuronal development. This redox signaling regulates neurogenesis and maturation, potentially offering new therapies for neurodevelopmental disorders.
Area of Science:
- Neuroscience
- Molecular Biology
- Biochemistry
Background:
- Nitric oxide (NO) acts as a signaling molecule with diverse functions.
- NO's actions are mediated by its redox properties, including S-nitrosylation.
- S-nitrosylation is a critical oxidative posttranslational modification of cysteine residues.
Purpose of the Study:
- To review the role of S-nitrosylation in neurogenesis and neuronal development.
- To highlight the impact of S-nitrosylation on key proteins involved in neuronal differentiation.
Main Methods:
- Focus on S-nitrosylation's direct modification of neuronal proteins.
- Review of studies investigating S-nitrosylation's effects on transcription factors like MEF2.
- Analysis of S-nitrosylated proteins in signaling networks crucial for brain development.
Main Results:
- S-nitrosylation directly impacts cytoplasmic and nuclear proteins in neurons.
- S-nitrosylation modulates neuronal development by modifying specific proteins.
- S-nitrosylation-mediated redox signaling is vital for neuronal differentiation and maturation.
Conclusions:
- S-nitrosylation is a rapidly advancing field in understanding neuronal development.
- Redox signaling via S-nitrosylation plays a significant role in brain development.
- Dysregulation of S-nitrosylation may link to neurodevelopmental disorders like ASD, suggesting therapeutic potential.
