Maintenance cognitive stimulation therapy: an economic evaluation within a randomized controlled trial
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Updated: Apr 19, 2026
Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke
Published on: June 6, 2025
Francesco D'Amico1, Amritpal Rehill1, Martin Knapp1
1Personal Social Services Research Unit, London School of Economics and Political Science, London, UK.
Background:
Cognitive Stimulation Therapy (CST) is effective and cost-effective for people with mild-to-moderate dementia when delivered biweekly over 7 weeks.
Aims:
To examine whether longer-term (maintenance) CST is cost-effective when added to usual care.
Methods:
Cost-effectiveness analysis within multicenter, single-blind, pragmatic randomized controlled trial; subgroup analysis for people taking acetylcholinesterase inhibitors (ACHEIs). A total of 236 participants with mild-to-moderate dementia received CST for 7 weeks. They were randomized to either weekly maintenance CST added to usual care or usual care alone for 24 weeks.
Results:
Although outcome gains were modest over 6 months, maintenance CST appeared cost-effective when looking at self-rated quality of life as primary outcome, and cognition (MMSE) and proxy-rated quality-adjusted life years as secondary outcomes. CST in combination with ACHEIs offered cost-effectiveness gains when outcome was measured as cognition.
Conclusions:
Continuation of CST is likely to be cost-effective for people with mild-to-moderate dementia.
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