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Developmental programing of thirst and sodium appetite
Andre S Mecawi1, Ana F Macchione2, Paula Nuñez3
1Department of Physiological Sciences, Institute of Biology, Federal Rural University of Rio de Janeiro, Seropedica, Brazil; Department of Physiology, Faculty of Medicine, University of Malaysia, Kuala Lumpur, Malaysia.
Neuroscience and Biobehavioral Reviews
|December 22, 2014
Summary
Early life challenges significantly program lifelong thirst and sodium appetite in animals and humans. This review explores the neuroendocrine and epigenetic factors influencing these essential behaviors for hydromineral balance.
Area of Science:
- Physiology
- Neuroendocrinology
- Developmental Biology
Background:
- Thirst and sodium appetite are crucial for maintaining hydromineral homeostasis.
- These behaviors are established early in the postnatal period.
- Pre- and postnatal stimuli influence adult water and salt intake patterns.
Purpose of the Study:
- To review how prenatal and postnatal challenges program lifelong thirst and sodium appetite.
- To identify involved neuroendocrine substrates.
- To discuss epigenetic mechanisms and clinical implications of early hydromineral disturbances.
Main Methods:
- Literature review of studies on thirst and sodium appetite development.
- Analysis of factors influencing water and salt intake programming.
- Examination of neuroendocrine and epigenetic mechanisms.
Main Results:
- Dietary changes, hydromineral challenges, hormonal disturbances, and lifestyle impact developmental programming.
- Specific neuroendocrine pathways are involved in regulating these behaviors.
- Epigenetic modifications may mediate long-term effects.
Conclusions:
- Early life experiences critically shape adult hydration and salt appetite.
- Understanding these developmental origins is vital for addressing hydromineral imbalances.
- This review highlights the long-term consequences of early-life challenges on physiological regulation.
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