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[State of homeostasis links in the children with intestinal colic]

O M Horlenko, U H Dubinina

    Likars'Ka Sprava
    |December 23, 2014
    PubMed

    Insights

    Children with intestinal colic often experience comorbidities like SARS and malnutrition. Key symptoms include flatulence, regurgitation, and elevated liver enzymes, with high IL8 and elastase antibody levels indicating inflammation and potential gut issues.

    Area of Science:

    • Pediatric Gastroenterology
    • Neonatal Homeostasis
    • Clinical Biochemistry

    Background:

    • Intestinal colic is a common condition in infants, impacting their homeostasis.
    • Understanding the associated comorbidities and clinical markers is crucial for effective management.
    • Previous research has explored various factors, but a comprehensive overview of homeostatic links in colic is needed.

    Purpose of the Study:

    • To investigate the homeostatic parameters and clinical characteristics in children suffering from intestinal colic.
    • To identify prevalent comorbidities and symptoms associated with intestinal colic in the pediatric population.
    • To analyze specific biochemical markers, including liver enzymes and inflammatory indicators, in affected children.

    Main Methods:

    • Retrospective analysis of clinical data from a cohort of children diagnosed with intestinal colic.
    • Documentation of comorbidities such as SARS, protein-energy malnutrition, pneumonia, and atopic dermatitis.
    • Assessment of clinical complaints including flatulence, regurgitation, and hyperbilirubinemia.
    • Biochemical analysis of Alanine Aminotransferase (ALT), Aspartate Aminotransferase (AST), Interleukin-8 (IL8), and antibodies to elastase.

    Main Results:

    • Common comorbidities included SARS (18.18%), protein-energy malnutrition (12.85%), pneumonia (8.57%), and atopic dermatitis (10.00%).
    • All children presented with flatulence (100%), while frequent regurgitation (88.57%) and hyperbilirubinemia (80.33%) were also highly prevalent.
    • Elevated ALT (41%) and AST (51.66%) levels were observed in a significant portion of children.
    • Increased IL8 levels (71.42%) and significantly elevated antibodies to elastase (100%) were detected, indicating inflammatory processes.

    Conclusions:

    • Children with intestinal colic exhibit a range of comorbidities and clinical symptoms that disrupt homeostasis.
    • Elevated liver enzymes, IL8, and antibodies to elastase suggest underlying inflammation and potential gastrointestinal dysfunction.
    • These findings highlight the importance of a comprehensive assessment of biochemical and clinical markers in managing pediatric intestinal colic.

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