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Continuous infusion of high-dose acyclovir for serious herpesvirus infections
C V Fletcher1, J A Englund, B Bean
1Department of Pharmacy Practice, University of Minnesota, Health Sciences Center, Minneapolis 55455.
Antimicrobial Agents and Chemotherapy
|August 1, 1989
Abstract:
Thirteen patients with herpesvirus infections who were unresponsive to at least 72 h of intermittent acyclovir administration received high-dose continuous infusion. Steady-state concentrations were maintained at between 20 and 98 mumol/liter. Of 12 patients who had continuous infusion for greater than 5 days, 7 (58%) resolved their infections, as determined by clinical and virologic parameters, suggesting that continuous infusion may succeed in some patients who do not respond to conventional therapy.