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Tunable rigidity of (polymeric core)-(lipid shell) nanoparticles for regulated cellular uptake

Jiashu Sun1, Lu Zhang, Jiuling Wang

  • 1Beijing Engineering Research Center for BioNanotechnology & CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for NanoScience and Technology, Beijing, 100190, P. R. China.

Advanced Materials (Deerfield Beach, Fla.)
|December 23, 2014
PubMed
Summary

Nanoparticle rigidity significantly impacts cellular uptake, with stiffer nanoparticles more effectively crossing cell membranes. Atomistic simulations reveal the underlying mechanism of this rigidity-dependent cellular entry.

Keywords:
biomedical applicationscellular uptakecore-shell nanoparticlesdrug deliverymicrofluidics

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