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Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
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Sex-dependent differences in renal angiotensinogen as an early marker of diabetic nephropathy

D de Alencar Franco Costa1, M Todiras, L A Campos

  • 1Center of Innovation, Technology and Education-(CITE), University Camilo Castelo Branco, Sao Jose dos Campos, Brazil.

Acta Physiologica (Oxford, England)
|December 23, 2014
PubMed
Abstract

Insights

Diabetic kidney injury shows significant sex differences, with males exhibiting higher albuminuria linked to renal angiotensinogen. Androgens may worsen male diabetic kidney damage independently of the renin-angiotensin system.

Area of Science:

  • Nephrology
  • Endocrinology
  • Molecular Biology

Background:

  • The renal renin-angiotensin system (RAS) plays a role in diabetic nephropathy.
  • Sex differences in diabetic kidney disease are not fully understood.

Purpose of the Study:

  • Investigate sex disparities in the renal RAS in diabetic nephropathy.
  • Examine the influence of androgens on diabetes-associated renal injury.

Main Methods:

  • Utilized streptozotocin-induced diabetic rat model.
  • Assessed renal injury via albuminuria and gene expression (collagen I, fibronectin).
  • Analyzed plasma and renal RAS components (angiotensinogen, renin activity, mRNA levels); tested anti-androgen flutamide.

Main Results:

  • Diabetic males showed significantly higher albuminuria and renal angiotensinogen mRNA than females.
  • Renal angiotensinogen mRNA levels strongly correlated with albuminuria in males.
  • Anti-androgen treatment reduced albuminuria in diabetic males, independent of RAS modulation.

Conclusions:

  • Renal angiotensinogen, not hepatic, is linked to diabetic albuminuria, contributing to sex-dependent renal injury.
  • Androgens may exacerbate albuminuria in males with diabetes through RAS-independent mechanisms.
Keywords:
albuminuriaandrogensdiabetesrenal angiotensinogensexual dimorphism

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