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Updated: Apr 19, 2026

Peptide-based Identification of Functional Motifs and their Binding Partners
Published on: June 30, 2013
Nef, the shuttling molecular adaptor of HIV, influences the cytokine network
Zulema Antonia Percario1, Muhammad Ali1, Giorgio Mangino2
1Department of Sciences, University Roma Tre, Rome, Italy.
Abstract:
Several viruses manipulate host innate immune responses to avoid immune recognition and improve viral replication and spreading. The viral protein Nef of Human Immunodeficiency Virus is mainly involved in this "hijacking" activity and is a well established virulence factor. In the last few years there have been remarkable advances in outlining a defined framework of its functions. In particular Nef appears to be a shuttling molecular adaptor able to exert its effects both on infected and non infected bystander cell. In addition it is emerging fact that it has an important impact on the chemo-cytokine network. Nef protein represents an interesting new target to develop therapeutic drugs for treatment of seropositive patients. In this review we have tried to provide a unifying view of the multiple functions of this viral protein on the basis of recently available experimental data.
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