Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antimicrobial Proteins01:23

Antimicrobial Proteins

15.6K
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
15.6K
Factors Affecting Protein-Drug Binding: Protein-Related Factors01:20

Factors Affecting Protein-Drug Binding: Protein-Related Factors

704
Drug binding to proteins is a key aspect of pharmacokinetics and can influence a drug's distribution, absorption, and elimination in the body. Several factors, including the drug's physiochemical properties, protein concentration, disease states, and the number of binding sites on the protein, influence this process.
The physicochemical properties of a drug play a significant role in its ability to bind to proteins. Lipophilic drugs, which dissolve in fats, oils, and lipids, can be...
704
Coordination of Gene Expression Processes in Bacteria01:29

Coordination of Gene Expression Processes in Bacteria

1.0K
The DNA replication, transcription, and translation processes are intricately coupled in bacteria, allowing efficient gene expression and rapid protein synthesis. While this physical and functional coordination is advantageous, it introduces challenges that bacteria overcome through specific regulatory mechanisms.Coupling of Replication, Transcription, and TranslationThe coupling of replication, transcription, and translation is a hallmark of bacterial gene expression. As the replisome unwinds...
1.0K
NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

10.9K
The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
10.9K
Types of RNA01:23

Types of RNA

74.4K
Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
74.4K
Cytoskeletal Proteins in Bacteria01:29

Cytoskeletal Proteins in Bacteria

4.5K
Bacterial cells were initially considered simple, randomly organized structures lacking a cytoskeleton. However, the discovery of cytoskeleton homologs in bacteria led to the change of this opinion. Bacterial cytoskeletal filaments regulate the cell shape, cell polarity, cell division, and partitioning of plasmids during cell division. It was later discovered that bacterial cytoskeletal proteins, mainly actin and tubulin homologs, are diverse compared to their eukaryotic counterparts. On the...
4.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The unique synaptic circuitry of specialized olfactory glomeruli in <i>Drosophila melanogaster</i>.

eLife·2025
Same author

Fungal endophytes with anti-fungal metabolites reduce symptoms of ash dieback in Fraxinus excelsior in a greenhouse experiment.

Fungal biology·2025
Same author

Innovative zinc-binding inhibitors of Legionella pneumophila ProA reduce collagen and flagellin degradation, TLR5 evasion, and human lung tissue inflammation.

European journal of medicinal chemistry·2025
Same author

Polyfloral nutritional resources promote bumble bee colony development after exposure to a pesticide mixture.

Ecotoxicology and environmental safety·2025
Same author

Deterministic Fabrication of Fluorescent Nanostructures Featuring Distinct Optical Transitions.

Nanomaterials (Basel, Switzerland)·2025
Same author

Wafer-scale nanofabrication of sub-5 nm gaps in plasmonic metasurfaces.

Nanophotonics (Berlin, Germany)·2024

Related Experiment Video

Updated: Apr 19, 2026

Identifying the Binding Proteins of Small Ligands with the Differential Radial Capillary Action of Ligand Assay DRaCALA
09:26

Identifying the Binding Proteins of Small Ligands with the Differential Radial Capillary Action of Ligand Assay DRaCALA

Published on: March 19, 2021

4.1K

FKBPs in bacterial infections.

Can M Ünal1, Michael Steinert2

  • 1Türk-Alman Üniversitesi, Fen Fakültesi, Istanbul, Turkey; Technische Universität Braunschweig, Institut für Mikrobiologie, Braunschweig, Germany.

Biochimica Et Biophysica Acta
|December 23, 2014
PubMed
Summary

FK506-binding proteins (FKBPs) with peptidyl-prolyl-cis/trans-isomerase (PPIase) activity are crucial in bacterial infections. Targeting these bacterial FKBPs offers a promising strategy for developing novel anti-infective drugs.

Keywords:
BacteriaDrug targetFK506-binding proteinInfectionMacrophage infectivity potentiator (Mip)Pathogen

More Related Videos

Bio-layer Interferometry for Measuring Kinetics of Protein-protein Interactions and Allosteric Ligand Effects
13:57

Bio-layer Interferometry for Measuring Kinetics of Protein-protein Interactions and Allosteric Ligand Effects

Published on: February 18, 2014

30.6K
Assays for Studying the Role of Vitronectin in Bacterial Adhesion and Serum Resistance
10:55

Assays for Studying the Role of Vitronectin in Bacterial Adhesion and Serum Resistance

Published on: October 16, 2018

8.7K

Related Experiment Videos

Last Updated: Apr 19, 2026

Identifying the Binding Proteins of Small Ligands with the Differential Radial Capillary Action of Ligand Assay DRaCALA
09:26

Identifying the Binding Proteins of Small Ligands with the Differential Radial Capillary Action of Ligand Assay DRaCALA

Published on: March 19, 2021

4.1K
Bio-layer Interferometry for Measuring Kinetics of Protein-protein Interactions and Allosteric Ligand Effects
13:57

Bio-layer Interferometry for Measuring Kinetics of Protein-protein Interactions and Allosteric Ligand Effects

Published on: February 18, 2014

30.6K
Assays for Studying the Role of Vitronectin in Bacterial Adhesion and Serum Resistance
10:55

Assays for Studying the Role of Vitronectin in Bacterial Adhesion and Serum Resistance

Published on: October 16, 2018

8.7K

Area of Science:

  • Microbiology
  • Biochemistry
  • Drug Discovery

Background:

  • FK506-binding proteins (FKBPs) possess peptidyl-prolyl-cis/trans-isomerase (PPIase) activity and bind immunosuppressive drugs.
  • FKBPs are immunophilins found in both eukaryotes and bacteria, playing roles in cellular processes.

Purpose of the Study:

  • To review bacterial virulence-associated FKBPs, specifically trigger factors and Mip-like PPIases.
  • To discuss the involvement of host FKBPs in bacterial infection mechanisms.

Main Methods:

  • Literature review focusing on bacterial FKBPs and their roles in virulence.
  • Analysis of host-pathogen interactions involving FKBPs.

Main Results:

  • Identified two main groups of bacterial virulence-associated FKBPs: trigger factors and Mip-like PPIases.
  • Highlighted the contribution of host FKBPs to bacterial infection processes.

Conclusions:

  • Bacterial PPIases represent viable targets for novel anti-infective therapies.
  • Current research explores pipecolinic acid, cycloheximide derivatives, and substrate-based inhibitors for drug development.
  • Synergistic efforts in drug development and basic research are recommended for advancing anti-infective strategies.