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Characterization of renal glomerular endothelin receptors in the rat
G Gauquelin1, G Thibault, R Garcia
1Laboratory of Experimental Hypertension and Vasoactive Peptides, Clinical Research Institute of Montreal, Quebec, Canada.
Biochemical and Biophysical Research Communications
|October 16, 1989
Abstract:
Specific receptors for Endothelin (Et) have been identified in the glomerulus of rat kidney. Human 125I-ET binds to a single population of high affinity receptors in glomerular membranes from normal rats with a mean equilibrium dissociation constant of 200 pM. The binding was time and temperature-dependent, saturable and reversible. The Et-receptor complex was not affected by either vasopressin, atrial natriuretic factor or angiotension II.