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Study of inhibition of platelet aggregation of 1,8-naphthyridine derivatives
P Ferrarini1, C Mori, M Criscuoli
1Istituto di Chimica Farmaceutica e Tossicologica Dell'Università di Pisa.
Abstract:
The antiplatelet activity of some 1,8-naphthyridine derivatives was studied. The compounds displayed different abilities in blocking the effects of ADP, collagen and arachidonic acid. Four of them showed an in vitro remarkable activity similar to that of dipyridamole and papaverine.