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Updated: Apr 19, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Recognizing lexical and semantic change patterns in evolving life science ontologies to inform mapping adaptation
Julio Cesar Dos Reis1, Duy Dinh2, Marcos Da Silveira2
1Faculty of Campo Limpo Paulista, Rua Guatemala, 167, 13231-230 Campo Limpo Paulista, SP, Brazil; Luxembourg Institute of Science and Technology, 29 Avenue John F. Kennedy, L-1855 Luxembourg, Luxembourg.
Maintaining life science ontology mappings is challenging due to frequent updates. This study introduces methods to automatically detect ontology changes, improving mapping adaptation strategies and accuracy.
Area of Science:
- Bioinformatics
- Ontology Engineering
- Life Sciences
Background:
- Life science ontologies evolve frequently, necessitating significant effort to maintain mappings.
- Automated methods for updating ontology mappings are crucial but lack detailed change descriptions.
- Current approaches often fail to capture nuanced concept evolution between ontology versions.
Purpose of the Study:
- To define and automatically recognize concept attribute change patterns in evolving ontologies.
- To evaluate the effectiveness of proposed methods for ontology mapping adaptation.
- To assess the impact of recognized change patterns on mapping strategies.
Main Methods:
- Developed methods to identify concept attribute change patterns based on attribute similarity.
- Proposed algorithms to automatically recognize these change patterns.
- Evaluated the performance of pattern recognition and its influence on mapping adaptation.
Main Results:
- Achieved Precision >60% and Recall >35% in identifying change patterns.
- Determined that recognized patterns impact ~66% of mapping adaptation actions positively.
- Demonstrated the influence of similarity coefficients on algorithm performance.
Conclusions:
- The approach effectively characterizes ontology evolution at the concept attribute level.
- Proposed change patterns are relevant for informed decision-making in ontology mapping adaptation.
- Experimental validation on real-world life science ontologies confirms the approach's efficacy.
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