[Bone and Calcium Research Update 2015. Basic mechanisms underlying calcium signaling and their biological

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Yasuo Mori1, Masayuki X Mori, Motohiro Nishida

  • 1Laboratory of Environmental Systems Biology, Graduate School of Environmental Studies and Laboratory of Molecular Biology, Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering Kyoto University, Japan.

Clinical Calcium
|December 23, 2014
PubMed

Insights

Calcium ion (Ca2+) acts as a crucial second messenger regulating cellular functions through precise mechanisms. This review explores Ca2+ channels, binding proteins, and signaling pathways, detailing their molecular basis and biological significance.

Area of Science:

  • Biochemistry and Molecular Biology
  • Cellular Physiology

Context:

  • Calcium ion (Ca2+) is a vital inorganic ion with a well-established role as a second messenger.
  • Cellular Ca2+ levels are tightly regulated by sophisticated molecular machinery.
  • Numerous proteins involved in Ca2+ signaling have been identified, with ongoing discoveries of new components.

Purpose:

  • To review the molecular mechanisms of Ca2+ signaling.
  • To discuss the biological significance of Ca2+ regulation.
  • To explore future directions in Ca2+ signaling research.

Summary:

  • This review focuses on Ca2+ channels, Ca2+-binding proteins, and the signaling pathways they control.
  • It examines the molecular underpinnings of these components and their roles in cellular processes.
  • The discussion encompasses the biological importance and potential future advancements in understanding Ca2+ signaling.

Impact:

  • Provides a comprehensive overview of Ca2+ signaling for researchers.
  • Highlights the complexity and importance of Ca2+ in biological systems.
  • Informs future research into therapeutic strategies targeting Ca2+ pathways.

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