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Updated: Apr 19, 2026

Efficient Neural Differentiation using Single-Cell Culture of Human Embryonic Stem Cells
Published on: January 18, 2020
Epigenetic mechanisms regulating differentiation of neural stem/precursor cells
Aliya Mari D Adefuin1, Ayaka Kimura, Hirofumi Noguchi
1Department of Stem Cell Biology & Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka City, Fukuoka, Japan.
Abstract:
Differentiation of neural stem/precursor cells (NS/PCs) into neurons, astrocytes and oligodendrocytes during mammalian brain development is a carefully controlled and timed event. Increasing evidences suggest that epigenetic regulation is necessary to drive this. Here, we provide an overview of the epigenetic mechanisms involved in the developing mammalian embryonic forebrain. Histone methylation is a key factor but other epigenetic factors such as DNA methylation and noncoding RNAs also partake during fate determination. As numerous epigenetic modifications have been identified, future studies on timing and regional specificity of these modifications will further deepen our understanding of how intrinsic and extrinsic mechanisms participate together to precisely control brain development.
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