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Related Experiment Video

Updated: Apr 19, 2026

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota

Published on: July 31, 2019

IBD: microbiota manipulation through diet and modified bacteria.

Hannah L Simpson¹, Barry J Campbell, Jonathan M Rhodes

¹Department of Gastroenterology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.

Digestive Diseases (Basel, Switzerland)

|December 23, 2014

Summary

This summary is machine-generated.

Altering the gut microbiota shows promise for treating Crohn's disease (CD) and ulcerative colitis (UC). Therapies like prebiotics and modified bacteria could offer new treatments for these inflammatory bowel diseases.

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Last Updated: Apr 19, 2026

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota

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Published on: July 31, 2019

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Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

Area of Science:

Gastroenterology
Microbiology
Immunology

Background:

Crohn's disease (CD) and ulcerative colitis (UC) are characterized by an altered intestinal microbiota.
Genetic associations suggest defects in the mucosal barrier and innate immune responses to bacteria in CD and UC.

Purpose of the Study:

To review therapeutic strategies targeting the intestinal microbiota in CD and UC.
To assess the potential of dietary modifications and genetically modified bacteria for treating CD and UC.

Main Methods:

A MEDLINE search was conducted using terms related to prebiotics, genetically modified bacteria, mucosal barriers, and inflammatory bowel diseases.
The review synthesized data from in vitro, animal, and clinical studies.

Main Results:

In vitro and animal studies show promise for microbiota-targeted therapies, including prebiotics, contrabiotics, phosphatidylcholine, genetically modified bacteria (expressing IL-10 or protease inhibitors), and Vitamin D.
Clinical trials indicate benefits of phosphatidylcholine in UC and Vitamin D in CD.

Conclusions:

Strategies targeting the microbiota and host defense mechanisms are promising therapeutic avenues for CD and UC.
Further investment in these microbiota-focused therapies is warranted.