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Related Experiment Video

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Robot-assisted Partial Splenectomy

Robot-assisted Partial Splenectomy

Published on: January 2, 2026

Case 213: primary splenic angiosarcoma.

John J Krol¹, Vera V Krol, Adrian Dawkins

¹From the Departments of Radiology (J.J.K., A.D., H.S.G.) and Pathology and Laboratory Medicine (V.V.K.), University of Kentucky, 128 Leader Ave, Lexington, KY 40508.

|December 23, 2014

Summary

This summary is machine-generated.

A 75-year-old woman with diabetes and GERD presented with worsening headaches and abdominal pain, ultimately succumbing to an undiagnosed condition despite extensive testing. This case highlights diagnostic challenges in complex medical presentations.

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Area of Science:

Internal Medicine
Hematology
Diagnostic Imaging

Background:

A 75-year-old woman with type II diabetes and gastroesophageal reflux disease presented with a 3-month history of progressive headaches, abdominal pain, and back pain.
She had a forehead mass and presented with anemia and severe thrombocytopenia refractory to treatment.

Observation:

Extensive diagnostic workup, including advanced imaging (MRI, CT, US) and invasive procedures (bone marrow biopsy, endoscopy, colonoscopy), was performed.
Infectious, neoplastic, and autoimmune causes were systematically excluded through comprehensive laboratory testing and biopsies.

Findings:

Despite a thorough investigation, the underlying cause of the patient's symptoms, cytopenias, and eventual rapid decline remained undiagnosed.
The patient's condition acutely worsened, leading to unresponsiveness and death on the 17th day of admission.

Implications:

This case underscores the challenges in diagnosing rare or atypical presentations of diseases.
It highlights the importance of considering a broad differential diagnosis even after initial negative investigations.
Further research may be needed to identify novel diagnostic markers or therapeutic strategies for unexplained complex conditions.