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Controlled Cortical Impact Model for Traumatic Brain Injury
Published on: August 5, 2014
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Interactions between traumatic brain injury and frontotemporal degeneration
Mariel B Deutsch1, Mario F Mendez, Edmond Teng
1Department of Neurology, University of California, Los Angeles, Calif., USA.
Dementia and Geriatric Cognitive Disorders
|December 23, 2014
Summary
Traumatic brain injury (TBI) may increase the risk of frontotemporal degeneration (FTD). TBI influences FTD subtypes
Area of Science:
- Neuroscience
- Neurology
- Neurodegenerative Diseases
Background:
- Previous studies in limited populations suggest a link between traumatic brain injury (TBI) and increased risk for frontotemporal degeneration (FTD).
- The National Alzheimer's Coordinating Center Uniform Data Set provides a larger cohort for investigating this association.
Purpose of the Study:
- To confirm and expand upon prior findings regarding TBI as a risk factor for FTD.
- To examine how TBI influences the clinical presentation and severity across different FTD subtypes.
Main Methods:
- Comparison of TBI prevalence between FTD patients and healthy controls.
- Assessment of cognitive, behavioral, functional, and global dementia severity in FTD patients with and without a history of TBI.
Main Results:
- Remote TBI with extended loss of consciousness (TBI-ext) was significantly more prevalent in individuals with FTD compared to controls (OR: 1.67).
- FTD patients with TBI-ext showed less functional and global impairment in the behavioral variant but increased behavioral pathology in the semantic variant.
Conclusions:
- Traumatic brain injury (TBI) is a potential risk factor for developing frontotemporal degeneration (FTD).
- TBI history can modify the clinical symptoms and disease severity within specific FTD subtypes, impacting patient outcomes.
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