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Related Experiment Video

Updated: Apr 19, 2026

Real-Time Intravital Multiphoton Microscopy to Visualize Focused Ultrasound and Microbubble Treatments to Increase Blood-Brain Barrier Permeability
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Intracranial perfusion imaging with ultrasound.

Stephen Meairs1, Rolf Kern

  • 1Department of Neurology, Universitätsmedizin Mannheim, University of Heidelberg, Mannheim, Germany.

Frontiers of Neurology and Neuroscience
|December 23, 2014
PubMed
Summary

Ultrasound perfusion imaging advances enable early stroke detection. This review covers real-time techniques for visualizing brain infarctions and hemorrhages, enhancing acute stroke patient assessment.

Area of Science:

  • Neurology
  • Medical Imaging
  • Radiology

Background:

  • Significant advancements in ultrasound perfusion imaging of the brain have occurred recently.
  • Various methods have demonstrated efficacy in the early identification of cerebral perfusion deficits in stroke patients.

Purpose of the Study:

  • To review the methodology of ultrasound perfusion imaging.
  • To discuss the safety aspects of this technique.
  • To present emerging clinical applications in acute stroke patients.

Main Methods:

  • Real-time low-mechanical index imaging simplifies parameter acquisition.
  • Contrast-specific imaging addresses previous limitations like shadowing and temporal resolution.
  • Focus on advanced ultrasound techniques for brain perfusion assessment.

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Main Results:

  • New possibilities for real-time visualization of brain infarctions and cerebral hemorrhages.
  • Improved detection of cerebral perfusion deficits.
  • Enhanced assessment of acute stroke.

Conclusions:

  • Ultrasound perfusion imaging is a valuable tool for acute stroke assessment.
  • Real-time, contrast-specific techniques offer significant advantages.
  • Further clinical applications are emerging for brain perfusion evaluation.