Related Experiment Video
Updated: Apr 19, 2026
03:58
Author Spotlight: Advancing Awake Nasotracheal Intubation with Flexible Video Rhino-Laryngoscopes
Published on: August 2, 2024
2.8K
Laryngeal inflammatory myofibroblastic tumor
Fábio M Girardi1, Ciro W Fontana, Ricardo G Kroef
1Department of Head and Neck Surgery, Hospital Santa Rita, Complexo Hospitalar Santa Casa, Porto Alegre, Brazil. fabiomgirardi@gmail.com.
Ear, Nose, & Throat Journal
|December 23, 2014
Summary
Inflammatory myofibroblastic tumors rarely affect the larynx. This case highlights a subglottic tumor causing airway obstruction, successfully treated with surgery.
Area of Science:
- Otolaryngology
- Pathology
Background:
- Inflammatory myofibroblastic tumor (IMT) is a rare neoplastic proliferation.
- Laryngeal involvement by IMT is exceptionally uncommon, with limited documented cases.
Observation:
- A 27-year-old male presented with acute upper airway obstruction.
- A subglottic mass was identified as the cause of obstruction.
Findings:
- Histopathological examination confirmed the mass as an inflammatory myofibroblastic tumor.
- The patient required emergency tracheotomy and subsequent partial laryngectomy for tumor removal.
Implications:
- This case underscores the importance of considering IMT in the differential diagnosis of laryngeal obstructive masses.
- Prompt surgical intervention can lead to favorable outcomes, even in cases with potential for local recurrence.
Related Concept Videos
01:22Myasthenia Gravis ll: Pathophysiology
14
The disease process of myasthenia gravis begins at the neuromuscular junction, where antibodies attack key proteins needed for muscle activation. This immune reaction weakens signal transmission, leading to the characteristic muscle fatigue and weakness that define the condition.Immune-Mediated DamageIn most individuals, antibodies target acetylcholine receptors (AChRs) on the postsynaptic membrane of muscle cells. By blocking acetylcholine binding, these antibodies prevent the nerve signal...
14
01:21Larynx
6.8K
The human larynx, often referred to as the voice box, is an intricate organ located in the neck. It serves as a pathway for air to enter the lungs during respiration and is an essential component of voice production.
Anatomy of the Larynx
The larynx consists of various components, including cartilage, muscles, and vocal cords. Its structure includes three large unpaired cartilages—the thyroid, cricoid, and epiglottis—and three smaller paired cartilages—the arytenoids,...
Anatomy of the Larynx
The larynx consists of various components, including cartilage, muscles, and vocal cords. Its structure includes three large unpaired cartilages—the thyroid, cricoid, and epiglottis—and three smaller paired cartilages—the arytenoids,...
6.8K
02:39lncRNA - Long Non-coding RNAs
10.2K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
10.2K
01:12Chronic Inflammation: Introduction
5
Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
5