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Gene therapy and imaging in preclinical and clinical oncology: recent developments in therapy and theranostics

Sebastian Gehrig1, Haider Sami, Manfred Ogris

  • 1Department for Pharmaceutical Chemistry, Faculty Center for Pharmacy, University of Vienna, Althanstraße 14, A-1090 Wien, Austria.

Therapeutic Delivery
|December 23, 2014
PubMed

Insights

Gene theranostics offer a promising new approach for treating and diagnosing disseminated cancer. This innovative strategy combines gene therapy with diagnostic imaging, potentially leading to effective treatments for currently incurable cancers.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biotechnology

Background:

  • Current treatments for disseminated cancer are limited in efficacy.
  • Gene therapy offers a potential new avenue for cancer treatment.
  • The theranostic paradigm integrates diagnosis and therapy.

Purpose of the Study:

  • To explore gene theranostics as an innovative approach for cancer treatment and diagnosis.
  • To highlight the role of gene vectors in tumor-specific nucleic acid delivery.
  • To advance the development of effective treatments for incurable cancers.

Main Methods:

  • Development of gene vectors for tumor-specific nucleic acid delivery.
  • Incorporation of reporter genes and imaging agents into gene delivery systems.
  • Preclinical studies and clinical trials in human and veterinary oncology.

Main Results:

  • Gene vectors are crucial for successful cancer gene therapy.
  • Functionalized gene vectors enable combined diagnostic and therapeutic functions.
  • Preclinical data demonstrate feasibility; clinical trials show encouraging preliminary results.

Conclusions:

  • Gene theranostics represent a significant advancement in cancer care.
  • This approach holds promise for treating currently incurable cancers.
  • Further clinical investigation is warranted to optimize gene theranostic strategies.

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